Top scorer Agard was forced to miss the 1-1 play-off draw at Preston on Saturday with a tight hamstring, picked up in training last Friday morning.
Meanwhile defender Brindley was taken off during the first half with a similar problem, with Frecklington also leaving the field with half an hour left due to a knock.
Evans is hoping all three will be okay, but the major doubt is over Brindley.
The Millers gaffer may be forced to shuffle his pack once again, particularly on the right hand side, with Nicky Adams still expected to be absent with a calf injury.
Richie Smallwood returns from a three game ban and may be included in the starting line up.