Knill, who was signed by Moore in 1997 has had success with the juniors and will be assisted by former Miller's striker Mark Robins.
Robins who left the club in search of first team football with Wednesday, has been taking his coaching badges and also a degree in management at Warwick.
Knilly told Sky Sports "I just got a phone call asking if I would take the first team,and obviously I said yes and now I'm doing this press conference, so thats just how its been really. I had no hesitation in taking the role, its a good opportunity for myself and Mark (Robins) who is coming with me, its a good opportunity for us both so there was no hesitation at all."
Chairman Peter Ruchiniewicz said "Alan Knill is very highly qualified and very well though of at the club, I've heard very good reports of him. We were very impressed with him when we put this to him, he is a very self possessed and self confident man who is clear on how he can work and organise a team and he can't wait to get started fully as the man in charge."