The centre-half missed Saturday's win at Crewe with a recurring back problem and he is not expected to be fit for the visit of the Cobblers.
Tom Newey will serve a one-match ban following his fifth caution of the season so Jamie Green will fill in at left-back.
Boss Ronnie Moore is hoping to have better news in the goalkeeping department with the potential return of number one Andy Warrington.
Warrington has missed the last two games following the birth of his daughter, who since suffered complications, but he trained with the squad on Monday and Moore must decide whether to hand him an instant recall or keep faith with Jamie Annerson.
Moore has no fresh injury concerns to contend with and has been boosted by the return to training of Dale Tonge, who has recovered from a metatarsal injury suffered in pre-season.
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