| COMPETITION | DATE | HOME | AWAY | ||
| LEAGUE ONE | Sa 07Aug 2021 | Rotherham | v | Plymouth | |
| EFL CUP | Tu 10Aug 2021 | Rotherham | v | Accrington | |
| LEAGUE ONE | Sa 14Aug 2021 | Wigan | v | Rotherham | |
| LEAGUE ONE | Tu 17Aug 2021 | Morecambe | v | Rotherham | |
| LEAGUE ONE | Sa 21Aug 2021 | Rotherham | v | Sheff Wed | |
| LEAGUE ONE | Sa 28Aug 2021 | Rotherham | v | Doncaster | |
| LEAGUE ONE | Sa 04Sep 2021 | Lincoln | v | Rotherham | |
| LEAGUE ONE | Sa 11Sep 2021 | Rotherham | v | Fleetwood | |
| LEAGUE ONE | Sa 18Sep 2021 | Bolton | v | Rotherham | |
| LEAGUE ONE | Sa 25Sep 2021 | Rotherham | v | Crewe | |
| LEAGUE ONE | Tu 28Sep 2021 | Rotherham | v | AFC W'bledon | |
| LEAGUE ONE | Sa 02Oct 2021 | Cheltenham | v | Rotherham | |
| LEAGUE ONE | Sa 09Oct 2021 | Charlton | v | Rotherham | |
| LEAGUE ONE | Sa 16Oct 2021 | Rotherham | v | Portsmouth | |
| LEAGUE ONE | Tu 19Oct 2021 | Rotherham | v | Wycombe | |
| LEAGUE ONE | Sa 23Oct 2021 | MK Dons | v | Rotherham | |
| LEAGUE ONE | Sa 30Oct 2021 | Rotherham | v | Sunderland | |
| LEAGUE ONE | Sa 13Nov 2021 | Shrewsbury | v | Rotherham | |
| LEAGUE ONE | Sa 20Nov 2021 | Rotherham | v | Cambridge U | |
| LEAGUE ONE | Tu 23Nov 2021 | Ipswich | v | Rotherham | |
| LEAGUE ONE | Sa 27Nov 2021 | Oxford | v | Rotherham | |
| LEAGUE ONE | Tu 07Dec 2021 | Rotherham | v | Gillingham | |
| LEAGUE ONE | Sa 11Dec 2021 | Rotherham | v | Burton | |
| LEAGUE ONE | Sa 18Dec 2021 | Cambridge U | v | Rotherham | |
| LEAGUE ONE | Su 26Dec 2021 | Accrington | v | Rotherham | |
| LEAGUE ONE | We 29Dec 2021 | Rotherham | v | Lincoln | |
| LEAGUE ONE | Sa 01Jan 2022 | Rotherham | v | Bolton | |
| LEAGUE ONE | Sa 08Jan 2022 | Doncaster | v | Rotherham | |
| LEAGUE ONE | Sa 15Jan 2022 | Fleetwood | v | Rotherham | |
| LEAGUE ONE | Sa 22Jan 2022 | Rotherham | v | Cheltenham | |
| LEAGUE ONE | Sa 29Jan 2022 | Crewe | v | Rotherham | |
| LEAGUE ONE | Sa 05Feb 2022 | Rotherham | v | Accrington | |
| LEAGUE ONE | Tu 08Feb 2022 | AFC W'bledon | v | Rotherham | |
| LEAGUE ONE | Sa 12Feb 2022 | Sheff Wed | v | Rotherham | |
| LEAGUE ONE | Sa 19Feb 2022 | Rotherham | v | Wigan | |
| LEAGUE ONE | Tu 22Feb 2022 | Rotherham | v | Morecambe | |
| LEAGUE ONE | Sa 26Feb 2022 | Plymouth | v | Rotherham | |
| LEAGUE ONE | Sa 05Mar 2022 | Rotherham | v | MK Dons | |
| LEAGUE ONE | Sa 12Mar 2022 | Wycombe | v | Rotherham | |
| LEAGUE ONE | Sa 19Mar 2022 | Rotherham | v | Shrewsbury | |
| LEAGUE ONE | Sa 26Mar 2022 | Sunderland | v | Rotherham | |
| LEAGUE ONE | Sa 02Apr 2022 | Portsmouth | v | Rotherham | |
| LEAGUE ONE | Sa 09Apr 2022 | Rotherham | v | Charlton | |
| LEAGUE ONE | Fr 15Apr 2022 | Rotherham | v | Ipswich | |
| LEAGUE ONE | Mo 18Apr 2022 | Burton | v | Rotherham | |
| LEAGUE ONE | Sa 23Apr 2022 | Rotherham | v | Oxford | |
| LEAGUE ONE | Sa 30Apr 2022 | Gillingham | v | Rotherham |